Diabetes and other autoimmune endocrine diseases

Poster

A Novel Population of β Cells That Resist Immunological Attack Develop During Progression of Autoimmune Diabetes in Nod mice

Thursday, June 15
5:45 PM - 7:00 PM

Type 1 diabetes (T1D) is a chronic autoimmune disease that involves immune mediated destruction of β cells. How β cells respond to immune attack is unknown. We identified a population of β cells during the progression of T1D in non-obese diabetic (NOD) mice that survives immune attack. This population develops from normal β cells confronted with islet infiltrates. Pathways involving cell movement, growth and proliferation, immune responses, and cell death and survival are activated in these cells. There is reduced expression of β cell identity genes and diabetes antigens and increased immune inhibitory markers and stemness genes. This new subpopulation is resistant to killing when diabetes is precipitated with cyclosphosphamide. Human β cells show similar changes when cultured with immune cells. These changes may account for the chronicity of the disease and the long term survival of β cells in some patients.

Jinxiu Rui

Postdoctoral Associate
Department of Immunobiology, Yale University

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    Songyan Deng

    Yale University

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      Arnon Arazi

      Broad Institute of MIT and Harvard

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        Ana Luisa Perdigoto

        Yale University

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          Zongzhi Liu

          Yale University

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            Kevan Herold

            Professor of Immunology
            Department of Immunobiology and Internal Medicine, Yale University

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              A Novel Population of β Cells That Resist Immunological Attack Develop During Progression of Autoimmune Diabetes in Nod mice



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