Reproductive immunology

Poster

Osteoporosis in Menopausal Women- a Need for Finding Biochemical Marker

Friday, June 16
6:15 PM - 7:30 PM

Mean serum E2 is significantly low with significant increase of Serum OST and Calcium in Cases than Control (E2; 43.40pg/ml vs 162.82pg/ml, OST; 15.87ng/ml, Calcium; 14.57mg/dl vs 8.37mg/dl). Significant negative correlation exists between Serum E2 and OST in both cases and control (cases ; r value =-0.628, p value =0.001, control; r=-0.314, p= 0.026).Serum E2 is significantly more low­­ with significant more increase of Serum OST and Calcium in Cases with positive history of joint pain (N=26) than with negative history ( N=24) (E2; Mean ± SD: 38.80±19.00 vs 48.37±22.03,OST; Mean ± SD: 19.22±6.76vs 12.25±7.00,Calcium; Mean ±SD:15.90±3.49 vs 13.12±3.23). Cases with positive history of fracture (N=6) also have more reduction of serum E2, with more increase of Serum OST and Calcium than with negative history (N=44) (E2; Mean±SD:22.50±6.12 vs 46.25±20.56, OST; Mean±SD:25.26±4.34 vs 14.59±7.12, Calcium; Mean±SD:17.14±3.98 vs 14.22±3.47). Cases with positive history of Calcium intake (N=13) have significant increase of Serum OST and Calcium than with negative history (N=37) (OST; Mean±SD:23.24±5.27 vs 13.29±6.65, Calcium: Mean ±SD: 16.43±3.76vs13.91±3.38).


In menopausal women, serum 17β-Estradiol (E2) is lowered as a result failing ovarian function. This decline is associated with increased Osteocalcin level, suggesting clear correlation between serum 17β-Estradiol (E2) and serum Osteocalcin. So they can be considered as biochemical markers osteoporosis in menopausal women. However, larger study is required to arrive at concrete conclusion.

Sahidur Rahman

Student and Trainee
Biotech Concern Ltd.

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    Ikhtiar Zahid

    biotech Concern

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      Ma Wadud

      Biotech Concern

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