Inflammatory bowel diseases

Oral

Involvement of Mait Cells in Crohn's Disease

Wednesday, June 14
6:15 PM - 7:45 PM

Crohn's disease (CD) is a chronic inflammatory disease characterized as intestinal disorder in consequence of a dysregulated response in mucosal immune system. Mucosal associated invariant T cells (MAIT), a population of T cells expressing Va7.2, a semi-invariant T cell antigen receptor, abundant in gut mucosa, have antimicrobial activity and ability to produce cytokines. Our study focus in the involvement of MAIT cells in CD. We analyzed mucosal tissue and peripheral blood from healthy controls and CD patients in treatment with anti-TNF (biological therapy) or corticosteroids. We observed an increase number of MAIT cells in mucosal tissue from CD patients, and increased numbers of MAIT cells Va7.2+CD161+CD8+TBET+CD45RO+ in both CD groups compared to healthy controls and between biological and corticosteroid groups. MAIT cells Va7.2+CD161+CD8+TBET+CD45RO- are increased in biological group compared with corticoid or control group. Furthermore, we observed that MAIT cells has higher TNFalpha expression in biological and corticosteroid groups when compared to healthy controls. Moreover, our data demonstrate that patients from biological group who are in clinical activity have an increase numbers of MAITCD8+TBET+CD45RO+ cells compared to patients in the same group but in clinical remission. Aditionally, our data indicate an increase number of MAIT cells with memory phenotype, more responsive than those with CD45RO- phenotype. Furthermore, these cells are producing large amounts of TNFalpha even in patients treated with anti-TNF inhibitors. So, we suggest that accumulation of MAIT cells in peripheral blood and mucosal tissue of CD patients, associated with increased TNFalpha production, contributes to progression of CD disease.

Ana Eduarda Carvalho

PhD student
Hospital Israelita Albert Einstein

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    Leticia D'argenio Garcia

    PhD student
    Hospital Israelita Albert Einstein

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      Claudia Concer Viero Nora

      PhD student
      Hospital Israelita Albert Einstein

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        Fernando Seefelder Flaquer

        MsC student
        Hospital Israelita Albert Einstein

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          Cristovão Luis P Mangueira

          Researcher
          Hospital Israelita Albert Einstein

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            Luiz Rizzo

            Researcher
            Hospital Israelita Albert Einstein

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              Karina Carvalho

              Researcher
              Hospital Israelita Albert Einstein

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