General autoimmunity

Poster

Anti-reticulin Autoantibodies Revisited: New Clinical Associations

Thursday, June 15
5:45 PM - 7:00 PM

Introduction: Reticulin is a type III collagen and specific anti-reticulin antibodies (ARA) had been used as diagnostic markers of celiac disease, although currently obsolete. Five types of indirect immunofluorescence (IIF) patterns associated with these autoantibodies have been observed, whose clinical implications are unknown.


Methods: Fifty-eight consecutive patients with positive ARA from a total of 490 serum samples routinely sent to perform triple tissue IIF to our laboratory were studied (NIKON Y-THS microscope and HELIOS® AESKU Systems). ARA patterns' distribution were as follows: R1: peritubular and periglomerular in kidney; perivascular and parenchymatic in liver; and intergastric fibers and subgladular muscle in the stomach. R2: Blood vessels in kidney and periportal in liver; blood vessels and intergastric fibers in the stomach. Rs: liver sinusoids and renal brush border. R3: Kuppfer's cells in liver.


Results: We observed 28 R2 out of 58 (48%); 19 Rs (33%); 7 R1 patients (12%); 4 R3 (7%). Of these, 34.5% of patients with positive ARA show chronic hepatopathy. A total of 41.4% reported chronic digestive disorders, the majority with R2 pattern. A 27.6% had signs of malignancy or familial cancer. Interestingly, 8 of R2 positive (28.6%) showed type 2 Diabetes Mellitus (T2DM).


Conclusions: Type 2 ARA was the commonest pattern followed by Rs. Most of ARA positive patients had history of chronic hepatopathy and other digestive disorders, as well as underlying cancer. An interesting preliminary result was a third part of R2 patients associated T2DM. Further studies may shed light of the clinical significance of these autoantibodies.

Luis sanchez-perez

HOSPITAL CLINICO SAN CARLOS

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    Jorge Molina

    Hospital Clínico San Carlos de Madrid

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      Natalia Zapata

      Hospital Clínico San Carlos de Madrid

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        Mercedes Castaño

        Hospital Clínico San Carlos de Madrid

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          María Ángeles Matey

          Hospital Clínico San Carlos

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            Miguel Fernandez-Arquero

            Hospital Clínico San Carlos de Madrid

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              Silvia Sanchez-Ramon

              Hospital Clínico San Carlos de Madrid

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