Immunity & infection
The therapy of the periapical lesions is a complex intervention, aiming to stimulate the reparatory processes of the periapical tissues. When the periapical lesions are treated surgically, the level of the immunosuppression depend on the complexity of the surgical intervention. The aim of this paper is to prove that there is a presence of the cytokines in the serum after the surgical and the endodontic treatment of these lesions. The research is conducted at 30 patients of different gender, with different scale of periapical lesions. At 15 of the patients is conducted the endodontic, and at the other 15, the surgical therapy. Before the therapy, analysis are made of the serum levels of the cytokines. 24 hours after the conducted treatment, the patients of both groups are tested, in order the serum levels of the cytokines to be registered. We determine the level of the cytokines with the use of a serum, by the method Elisa (Enzyme Linked Immunosorbent Assay). The acquired results of the endodontic treatment has shown statistically significant increase. After the surgical treatment, their values were increased too. This points to the fact that the tissue trauma is a cause for increasing of the levels of the cytokines, which are responsible in the systemic immunological response. It is an imperative that the decision of this issue should favor the endodontic procedure, and to minimize the invasive surgical method.