Immunity & infection

Oral

Systemic Lupus Erythematosus Patients with Infections Present Lower Expression of tlr2 in cd14+, cd16+ Monocytes: Preliminary Results of a Prospective Cohort Study

Wednesday, June 14
6:15 PM - 7:45 PM

Introduction: The immune system abnormalities in patients with systemic lupus erythematosus (SLE) may predispose them to the development of infections, which is one of the leading causes of morbidity and mortality. The objective of this study is to describe the immunologic factors related to infections development in patients with SLE.



Patients and methods. Fifty-two patients with SLE according to the ACR or SLICC criteria were prospectively followed-up during a median time of 6 (1-9) months. Clinical features were assessed at baseline, one and three months later. With multiparametric flow citometry we measured the percentage and absolute numbers of CD4+, CD8+, NK cells, monocytes subsets, T helper subpopulations, regulatory T cells and B lymphocytes as well as TLR2 mean fluorescence intensity and percentage and absolute number of monocytes subsets expressing TLR2.



Results: Eight patients (15.3%) presented an infection after a median time of 4.5 months. At baseline, patients with infections presented higher percentage of B cells (43.8 (21.2) vs 17.9 (16.3), p=0.029) and it correlated moderately with the development of infection ρ 0.5, p=0.028). Likewise, they had lower baseline percentage of CD14+/CD16+ monocytes expressing TLR2 (78.9 (29) vs 97.4 (4.2), p=0.007). In the following three months, patients with infections had higher percentage of Th17 cells (0.33 vs 0.09%, p=0.002).



Conclusions: Immunologic abnormalities such as low percentage of TLR2 positive CD14+/CD16+ monocytes, higher percentage of B-cells at baseline and higher Th17 cells three months later are more frequently present in lupus patients that developed infections during prospective follow-up.

Jiram Torres-Ruíz

Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán

Presentation(s):

    Send Email for Jiram Torres-Ruíz

    Jorge Alcocer-Varela

    Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán

    Presentation(s):

      Send Email for Jorge Alcocer-Varela

      Ana Barrera-Vargas

      Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

      Presentation(s):

        Send Email for Ana Barrera-Vargas

        Roberto Reyna-de la Garza

        Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán

        Presentation(s):

          Send Email for Roberto Reyna-de la Garza

          Sandra Morales-Padilla

          Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán

          Presentation(s):

            Send Email for Sandra Morales-Padilla

            Ricardo Vázquez-Rodríguez

            Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán

            Presentation(s):

              Send Email for Ricardo Vázquez-Rodríguez

              Diana Gomez-Martin

              Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

              Presentation(s):

                Send Email for Diana Gomez-Martin


                Assets

                Systemic Lupus Erythematosus Patients with Infections Present Lower Expression of tlr2 in cd14+, cd16+ Monocytes: Preliminary Results of a Prospective Cohort Study



                Attendees who have favorited this

                Send Email for Systemic Lupus Erythematosus Patients with Infections Present Lower Expression of tlr2 in cd14+, cd16+ Monocytes: Preliminary Results of a Prospective Cohort Study