Genetics

Oral

Predominant Male Prevalence of Hla b27 Alleles in Referred Patients to a Tertiary Medical Centre of Bangladesh

Friday, June 16
6:15 PM - 7:30 PM

Background: Human Leukocyte Antigen B27 (HLA-B27) (subtypes B*2701-*2759) is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) is strongly associated with ankylosing spondylitis (AS) and other associated inflammatory diseases, referred to collectively as 'spondyloarthritis'. The Prevalence of HLA-B27 varies regionally. This is the first report on the prevalence of HLA-B27 in referred patients in a tertiary medical centre of Bangladesh.


Methods: 2651 referred patients to Popular Diagnostic Centre Ltd., Dhaka from October, 2015 to December, 2016 with the complaints of back pain, joint pain, eye pain etc. has been included. The test was performed in LightCycler 480 (Roche Applied Sciences, Switzerland) platform using LightMix HLA-B27 kits from TIB Molbiol Gmbh (Germany).


Results: Among 2651 referred adult patients (21 to 68 years), 1551 were male (58.5%) and 1100 were female (41.5%). Overall, 715 (27%) has been detected positive and 1936 (73%) were negative for HLA-B27. 29% (451) of male referred patients and 14% (154) of female patients were found positive. Significant association (p


Conclusion: Female referred patients were found more protective than compared with male. Epidemiological studies with large cohort may be undertaken to strengthen this finding in future.


Md. Sohrab Alam

Senior Research Officer
Department of Immunology, BIRDEM, Dhaka

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    Sajoy Kanti Saha

    PhD Student
    Department of Biochemistry & Molecular Biology,University of Dhaka

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      Md Zakir Hossain Bhuiyan

      Research Assistant
      Department of Immunology, BIRDEM Hospital, Dhaka

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        AHM Nurun Nabi

        Professor
        Department of Biochemistry & Molecular Biology,University of Dhaka

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          Abu Shahriar Zahedee

          Managing Director
          Oncos Molbiol Ltd, Dhaka

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            Ashesh Kumar Chowdhury

            Professor
            Department of Immunology, BIRDEM, Dhaka

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              Predominant Male Prevalence of Hla b27 Alleles in Referred Patients to a Tertiary Medical Centre of Bangladesh



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