Recurrent urinary tract infections (UTIs) causing Escherichia coli (E. coli) pose a significant health threat by evading the immune system via internalization into host cells. In absence of vaccines, antibiotics are the main line of treatment for UTIs, but their overuse contributes towards bacterial resistance, resulting in worldwide public health concern. Thus, it is critical to develop novel therapeutics for UTIs. Nanodiamonds (NDs) are advantageous over conventional nanomaterials as they can be functionalized to adsorb therapeutics and develop novel, slow drug-releasing, targeted delivery systems. Safety studies demonstrate that NDs display minimal toxicity in variety of cells compared to carbon nanotubes. The objective of the current study was to investigate the ability of internalized NDs to kill E. coli that invade bladder cells.
Post doctoral fellow
Oklahoma State University Center for Health Sciences
Oklahoma State University-Center for Health Science
Oklahoma State University-Center for Health Sciences