Diabetes and other autoimmune endocrine diseases

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Relation of Islets Cell Antibody with Beta Cell Function in Type Ii Diabetic Patients of Bangladesh

Thursday, June 15
5:45 PM - 7:00 PM

Background: Presence of Islet cell autoantibody (ICA) at the time of diagnosis predicts deteriorating β-cell function of pancreas measured by C-peptide in type II diabetic patients. ICA positivity and measurement of C-peptide may predict early insulin requirement.


Objective: To assess pancreatic β cell function (measured by C-peptide) in patients with ICA positive and negative type II diabetic patients.


Methods: 173 type II diabetic adult patients of both sexes was selected and tested for presence of ICA autoantibody and C-peptide level using ELISA kits (both from DRG, USA) at the time of diagnosis, after 6 month and one year interval.

Results: Statistically significant difference was found in respect of ICA value in 173 type II DM patients (p < 0.001). ICA positive (12.7%) type II patients' mean value was 1.72±0.64 and was 0.55±0.16 in ICA (83.3%) negative cases. No statistically significant difference was found in age, gender and BMI in ICA positive and negative patients. The mean C-peptide level was 8.20±4.78 ng/ml in patients' positive for ICA antibody. After six months and one year follow up the mean C-peptide was 3.93±3.38 ng/ml and 2.50±2.05 ng/ml respectively. The changes of mean C-peptide was statistically significant (p < 0.001) in ICA positive patients after six months follow up in comparison to non-ICA negative patients.


Conclusion: We found deteriorating pancreatic β-cell function among ICA positive type II diabetic patients much earlier than found elsewhere in other studies (2-3 years). They may need insulin (instead of oral) much earlier for effective control of diabetes.

Ashesh Kumar Chowdhury

Professor
Department of Immunology, BIRDEM, Dhaka

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    Saimun Nahar Rumana

    Lecturer
    Department of Microbiology, Ibrahim Medical College

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      Mansura Khan

      Assistant Professor
      Department of Immunology, BIRDEM

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        Abu Taher Sarker

        Senior Medical Technologist
        Department of Immunology, BIRDEM

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