Immunity & infection

Oral

cd8+cd28-cd127locd39+ Treg Expansion: A New Pathogenic Mechanism for Hiv Infection?

Thursday, June 15
5:45 PM - 7:00 PM

HIV-associated immunodeficiency is related to loss of CD4+ T cells. This mechanism does not explain certain manifestations of HIV disease such as immunodeficiency events in patients with >500 CD4+ T cells/ml or occurrence of non-AIDS tumours. CD8+CD28-CD127lowCD39+ T cells are regulatory T lymphocytes highly concentrated within tumor microenvironment. Here we show that HIV-infected patients have elevated circulating levels of functional CD8+CD28-CD127lowCD39+ T regulatory cells. These cells have antigen specificity against HIV proteins, suggesting their origin from HIV-specific T lymphocytes. Their frequency post anti-retroviral therapy (ART) correlates with HIV viremia, CD4+ T cell count and immune activation markers, suggesting their pathogenic involvement in AIDS- or non-AIDS related complications. Their increase after initiation of ART heralds a lack of virological or clinical response: hence their monitoring is clinically relevant.

Gilberto Filaci

Associate Professor
Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa

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    Daniela Fenoglio

    Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa

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      Chiara Dentone

      Infectious Diseases Department, Sanremo Hospital

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        Alessio Signori

        Department of Health Sciences, University of Genoa

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          Antonio Di Biagio

          Infectious Disease Unit, IRCCS Azienda Ospedaliero Universitaria San Martino – IST - Istituto Nazionale per la Ricerca sul Cancro, Genoa

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            Alessia Parodi

            Centre of Excellence for Biomedical Research, University of Genoa

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              Francesca Kalli

              Centre of Excellence for Biomedical Research, University of Genoa

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                Giorgia Nasi

                Centre of Excellence for Biomedical Research, University of Genoa

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                  Monica Curto

                  Centre of Excellence for Biomedical Research, University of Genoa

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                    Giovanni Cenderello

                    Infectious Diseases Dept, Galliera Hospital, Genoa

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                      Pasqualina De Leo

                      Infectious Diseases Dept, San Paolo Hospital, Savona

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                        Valentina Bartolacci

                        S.M. Misericordia Hospital, Albenga

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                          Giancarlo Orofino

                          Infectious Diseases Dept, Amedeo di Savoia Hospital, Turin

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                            Laura Nicolini

                            Department of Health Sciences, University of Genoa

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                              Lucia Taramasso

                              Infectious Disease Unit, IRCCS Azienda Ospedaliero Universitaria San Martino – IST - Istituto Nazionale per la Ricerca sul Cancro, Genoa

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                                Edoardo Fiorillo

                                Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Sede Secondaria IRGB, Lanusei

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                                  Valeria Orrù

                                  Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Sede Secondaria IRGB, Lanusei

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                                    Paolo Traverso

                                    Department of Surgical Science and Integrated Diagnostics, University of Genoa

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                                      Bianca Bruzzone

                                      Hygiene Unit, Infectious Disease Unit, IRCCS Azienda Ospedaliero Universitaria San Martino – IST - Istituto Nazionale per la Ricerca sul Cancro, Genoa

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                                        Federico Ivaldi

                                        Centre of Excellence for Biomedical Research, University of Genoa

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                                          Eugenio Mantia

                                          Infectious Diseases Dept, SS. Antonio, Biagio, Cesare Arrigo Hospital, Alessandria

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                                            Michele Guerra

                                            Infectious Diseases Dept, Sant'Andrea Hospital, La Spezia

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                                              Simone Negrini

                                              Centre of Excellence for Biomedical Research and Department of Internal Medicine, University of Genoa

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                                                Mauro Giacomini

                                                Department of Informatics, Bioengineering, Robotic and System Engineering, University of Genoa,

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                                                  Sanjay Bhagani

                                                  Department of Infectious Diseases/HIV Medicine, Royal Free Hospital, NHS, London, UK

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                                                    cd8+cd28-cd127locd39+ Treg Expansion: A New Pathogenic Mechanism for Hiv Infection?



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