Immunity & infection
In murine schistosomiasis, previous observations identified that failure to modulate the anti-egg CD4 T helper response from a Th1-type to Th2-type, directly correlates with the disproportional immunodominance of the major egg antigen Sm-p40234-246 over the I-Ak MHCII antigen presentation pathway and severe liver immunopathology. To analyze the contribution of Sm-p40234-246 immunodominance to liver immunopathology, we developed a strategy to either enhance or reduce an epitope's immunodominance in the context of its I-A MHCII restriction, to verify the ensuing effects on immunopathology. This strategy revealed that the severity of the disease directly correlates with the degree of immunodominance of an epitope suggesting that exacerbated immunodominance constitutes an important factor in the genesis and severity of this, and maybe other murine and Human CD4 mediated diseases, which could be manipulated to prevent or modify their outcome.
Head of research and development