Autoimmune rheumatologic diseases
Background: Behçet's disease (BD) is a chronic multisystem inflammatory disease of unknown aetiology. Recent studies suggest that several immunological abnormalities may play pathogenetic role in BD. In BD, increased release of proinflammatory cytokines and chemokines and, peptide hormones may play a role in inflammatory stages of the disease. Recent studies have suggested the potential role of vitamin D and vitamin D receptor (VDR) in modulating the immune response and VDR's inflammatory or anti-inflammatory effects. In this study, we analyzed the possible role of serum VDR levels in the pathogenesis of BD.
Materials: 57 patients with BD and 59 healthy controls (24 female,35 male; mean age 34.3 ± 4.7 years) were enrolled in this study. Twenty-three patients were in active stage (8 female, 15 male, mean age; 33,7 ± 4.2 years, mean disease duration 11.7±6,9 years) and 34 patients were in inactive stage (11 female,23 male, mean age;34,6 ± 4.3 years, mean disease duration; 10,5 ± 4,7 years). Serum VDR levels were determined by ELISA.
Results: The mean serum VDR levels were 65.1±25.9 ng/ml in healthy controls, 15.2±9.8 ng/ml in active BD patients and 33.5±13.5 ng/ml in inactive BD patients. Serum VDR levels were significantly low in patients with BD compared with healthy controls (p < 0.01). Serum VDR levels were significantly high in active BD patients compared with in inactive BD patients (p < 0.001).
In this study, it was observed that; the serum VDR level may be an indicator for activity of BD.