Immunity & infection
MGUS is diagnosed in the patients when monoclonal protein is present in the blood with the concentration under 3 g/dL, clonal bone marrow plasma cells are under 10%, and other symptoms are absent. Despite the lack of any organ damage, and independently from the transformation to MM, MGUS patients have lower life expectancies and higher risks of bacterial infections and other condition like vein thrombosis, renal, heart and liver disorders.
NGAL is synthetized in the bone marrow and stored in the neutrophils in complex with gelatinase. The main function of NGAL is to bind to bacterial siderophores and by this way limit its growth. Therefore NGAL is recognized as the factor that mediates innate immune response and protects from infections.
The goal of the study was to assess serum and urine NGAL in 46 MGUS patients. The control group consisted of 23 healthy subjects matched for age and sex.
Serum and urine NGAL were measured with an immunoenzymatic method.
Serum level of NGAL in MGUS patients was lower than in healthy patients. This was not observed in case of urine NGAL. There was also no correlation between serum and urine NGAL.