Manipulating T Follicular Helper Cells and the Germinal Center

Friday, June 16
1:00 PM - 2:45 PM

Learning Objectives:

Terri Laufer

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Shane Crotty

Professor
LJI. La Jolla Insitute for Allergy & Immunology.

Shane Crotty graduated from MIT and then obtained his Ph.D. at the University of California, San Francisco, USA in 2001. He carried out postdoctoral studies at Emory University, USA, with Rafi Ahmed before starting his laboratory at the La Jolla Institute for Allergy & Immunology (LJI), USA, in 2003, where he is now a full professor. Dr. Crotty’s lab studying the fundamental immunology underlying the functions of vaccines. Initially trained in molecular virology and then viral immunology, Crotty’s laboratory focuses on both the basic immunology of T follicular helper (Tfh) CD4 T cells (Science 2009, Ann Rev Immunology 2011, Immunity 2013) as well as the central roles of germinal centers and memory in vaccine immunology (Science 2016, Cell Reports 2016). Dr. Crotty was named a Pew Scholar in Biomedical Sciences in 2005, and was the 2012 recipient of the American Association of Immunologists (AAI)-BD Biosciences Investigator Award, for outstanding early-career research contributions to the field of Immunology. He was recently named a 2016 Thompson Reuters ISI Highly Cited Researcher, ostensibly a tabulation of the most influential 125 immunologists in the world during the period 2004-2014.

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Marcus Clark

Chief, Section of Rheumatology
University of Chicago

Marcus Clark, M.D., Professor at University of Chicago, Departments of Medicine and Pathology, Gwen Knapp Center for Lupus and Immunology Research, Chief, Section of Rheumatology and Director, Medical Scientist Training Program.
Our laboratory has a long-standing interest in B cell antigen receptor (BCR) signaling and how BCR dependent processes regulate specific cell fate decisions and contribute to disease pathogenesis. Our translational studies have focused on how in situ adaptive immune responses drive tubulointerstitial inflammation in human lupus nephritis. For these studies, we have collaborated to develop novel image analysis tools (Cell Distance Mapping) to quantify and infer functional relationships between different T cell and antigen presenting cell populations in situ. We have also applied single cell technologies to understand B cell selection at sites of inflammation. I have used my expertise in B cell biology and human autoimmunity to establish a NIH-funded Autoimmunity Center of Excellence. This center is providing a collaborative platform for human-focused autoimmune studies in Rheumatology, Neurology, Gastroenterology and Nephrology. In our basic science studies, we have most recently been working to understand how signals initiated through the pre-BCR, in conjunction with those delivered through the IL-7 receptor, coordinate cell cycle progression with immunoglobulin light chain recombination. In the periphery, we have focused on the molecular mechanisms of receptor endocytosis and endocytic trafficking and how these mechanisms influence BCR trafficking and cell fate.

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Arlene H. Sharpe

George Fabyan Professor of Comparative Pathology
Harvard Medical School
Harvard Medical School

Arlene Sharpe, MD, PhD is the George Fabyan Professor of Comparative Pathology, Head of the Division of Immunology, and Interim Co-Chair of the Department of Microbiology and Immunobiology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women’s Hospital, an Associate Member at the Broad Institute of MIT and Harvard, Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center, and Co-Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital.

Dr. Sharpe earned her MD and PhD degrees from Harvard Medical School and completed her residency in Pathology at Brigham and Women’s Hospital.

Dr. Sharpe is a leader in the field of T cell costimulation. Her laboratory has discovered and elucidated the functions of T cell costimulatory pathways, including the immunoinhibitory functions of the CTLA-4 and PD-1 pathways, which have become exceptionally promising targets for cancer immunotherapy. Her laboratory currently focuses on the roles of T cell costimulatory pathways in regulating T cell tolerance and effective antimicrobial and antitumor immunity and translating this fundamental understanding into new therapies for autoimmune diseases and cancer. Dr. Sharpe has published over 300 papers and was listed by Thomas Reuters as one of the most Highly Cited Researchers (top 1%) in 2014 and 2015 and a 2016 Citation Laureate. She received the William B. Coley Award for Distinguished Research in Tumor immunology in 2014 for her contributions to the discovery of PD-1 pathway.

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