Member Society Symposia

Update on Animal Models and Pre-Clinical Targets for Immune Mediated Uveitis

Wednesday, June 14
12:45 PM - 4:45 PM

Sponsored By: 

Experimental models of uveitis have been instrumental in defining the modern understanding of immune mechanisms driving ocular inflammation, and will continue to play a central role in answering the challenging questions that remain. This symposium will highlight the important insights that new animal models are providing to the foundation of work established by the traditional Experimental Autoimmune Uveitis (EAU) model, the role advanced imaging is playing in animal studies, and outline the most exciting mechanistic developments identified in animal systems that hold the promise for clinical implementation in humans.

Chairs:
Kathryn Pepple, MD, PhD; Phoebe Lin, MD, PhD

Agenda:
12:45 p.m. Intro and Welcome

12:50 p.m. Mirroring the Clinical and Immunological Complexity of Autoimmune Uveitis in Animal Models
Rachel Caspi, PhD, National Institutes of Health

1:15 p.m. The Role for PD-1 in Experimental Autoimmune Uveitis
Lynn Gordon, MD, PhD, University of California, Los Angeles

1:40 p.m. Dysregulation of Innate Pathways in Ocular Autoimmunity
Holly Rosenzweig, PhD, Oregon Health and Science University

2:05 p.m. Ontogeny and Characterization of Eye Macrophages in Health and Disease
Daniel Saban, PhD, Duke University

2:25 p.m. Multimodal Non-invasive Imaging for Quantitative Assessment of Inflammation in Animal Models of Uveitis
Kathryn Pepple, MD, PhD, University of Washington

2:50 p.m. - Coffee Break

3:20 p.m. Chasing Immune Cells in the Eye: From Mouse to Man
Colin Chu, PhD, University of Bristol

3:45 p.m. Therapeutic Targeting of Pathogenic Lymphocytes That Mediate Uveitis
Charles Egwuagu, PhD, MPH, National Institutes of Health

4:10 p.m. Predicting the Future of Uveitis Treatment: Top Targets and Therapies on the Horizon
Phoebe Lin, MD, PhD, Casey Eye Institute

4:45 p.m. Panel Discussion


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Update on Animal Models and Pre-Clinical Targets for Immune Mediated Uveitis



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