Thematic

A Defined Structure for the Immune System That Reflects Immune Surveillance and Mechanistic Processes

Saturday, June 17
1:00 PM - 1:25 PM

Garry P. Nolan

Rachford and Carlota Harris Professor
Stanford University

Dr. Nolan, Rachford and Carlota A. Harris Professor in the Department of Microbiology and Immunology at Stanford University School of Medicine. Trained with Leonard Herzenberg (Ph.D.) and Nobelist Dr. David Baltimore (postdoctoral work for the first cloning/characterization of NF-κB p65/RelA and the development of 293T rapid retroviral production systems). Published over 190 research papers, holds 17 US patents, and one of the top 25 inventors at Stanford University. Dr. Nolan’s areas of research include hematopoiesis, cancer and leukemia, autoimmunity and inflammation, and computational approaches for network and systems immunology. Recent efforts are focused on a single cell analysis advance using a mass spectrometry-flow cytometry hybrid device (CyTOF). The approach uses an advanced ion plasma source to determine the levels of tagged reagents bound to cells enabling a vast increase in the number of parameters that can be measured per cell. Another innovation is termed molecular ion beam imaging (MIBI) a system that also uses mass tags that will enable sub-light imaging (5 nm resolution) of tissue sections with 50 or more parameters per image. His laboratory has already begun a large scale mapping of the hematopoietic hierarchy in healthy human bone marrow at an unprecedented level of detail. Dr. Nolan’s efforts are directed to enable a deeper understanding not only of normal immune function, trauma, and other inflammatory events but also detailed substructures of leukemias and solid cancers — which will enable wholly new understandings that will enable better management of disease and clinical outcomes.

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A Defined Structure for the Immune System That Reflects Immune Surveillance and Mechanistic Processes



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