Thematic

Neutrophils as Players and Therapeutic Targets in Systemic Autoimmunity

Friday, June 16
1:40 PM - 2:05 PM

Learning Objectives:

Mariana J. Kaplan

Senior Investigator and Chief, Systemic Autoimmunity Branch
National Institute of Arthritis and Musculoskeletal and Skin Diseases/National Institutes of Health

Mariana J. Kaplan, MD is Senior Investigator and Chief of the Systemic Autoimmunity Branch at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health. Dr. Kaplan's research has focused on identifying mechanisms of organ damage and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity promotes end-organ damage in systemic lupus erythematosus, rheumatoid arthritis and other systemic autoimmune diseases. Recently, her research has focused on identifying abnormalities of neutrophil subsets and the role of neutrophil extracellular traps (NETs) in lupus, vasculitis and rheumatoid arthritis, both of which may contribute to the development of autoimmune responses and to end-organ damage. Dr. Kaplan also has an interest in identifying novel therapeutic targets that may prevent premature vascular damage in systemic autoimmunity, as well as the role of environmental triggers in the induction of autoimmunity. Moreover, she has led clinical trials to identify mechanisms that reduce blood vessel dysfunction in autoimmune and chronic inflammatory disorders.

Presentation(s):

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Neutrophils as Players and Therapeutic Targets in Systemic Autoimmunity



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