Thematic

Dissecting In Situ Adaptive Cell Networks in Human Inflammation

Friday, June 16
1:40 PM - 2:05 PM

Learning Objectives:

Marcus Clark

Chief, Section of Rheumatology
University of Chicago

Marcus Clark, M.D., Professor at University of Chicago, Departments of Medicine and Pathology, Gwen Knapp Center for Lupus and Immunology Research, Chief, Section of Rheumatology and Director, Medical Scientist Training Program.
Our laboratory has a long-standing interest in B cell antigen receptor (BCR) signaling and how BCR dependent processes regulate specific cell fate decisions and contribute to disease pathogenesis. Our translational studies have focused on how in situ adaptive immune responses drive tubulointerstitial inflammation in human lupus nephritis. For these studies, we have collaborated to develop novel image analysis tools (Cell Distance Mapping) to quantify and infer functional relationships between different T cell and antigen presenting cell populations in situ. We have also applied single cell technologies to understand B cell selection at sites of inflammation. I have used my expertise in B cell biology and human autoimmunity to establish a NIH-funded Autoimmunity Center of Excellence. This center is providing a collaborative platform for human-focused autoimmune studies in Rheumatology, Neurology, Gastroenterology and Nephrology. In our basic science studies, we have most recently been working to understand how signals initiated through the pre-BCR, in conjunction with those delivered through the IL-7 receptor, coordinate cell cycle progression with immunoglobulin light chain recombination. In the periphery, we have focused on the molecular mechanisms of receptor endocytosis and endocytic trafficking and how these mechanisms influence BCR trafficking and cell fate.

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Dissecting In Situ Adaptive Cell Networks in Human Inflammation



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