Category: Autoimmune rheumatologic diseases

F.12 - Increased Levels of Sputum Antibodies to a Subset of Citrullinated Peptide Antigens Correlate with Sputum Neutrophil Extracellular Trap Levels in Subjects At-risk for Future Ra

Friday, Jun 16
6:15 PM – 7:30 PM

Emily Bowers

University of Colorado School of Medicine
Aurora, Colorado

Kevin Deane

University of Colorado School of Medicine
Aurora, Colorado

Michael Holers

University of Colorado School of Medicine
Aurora, Colorado

Mariana J. Kaplan

Senior Investigator and Chief, Systemic Autoimmunity Branch
National Institute of Arthritis and Musculoskeletal and Skin Diseases/National Institutes of Health
Bethesda, Maryland

Mariana J. Kaplan, MD is Senior Investigator and Chief of the Systemic Autoimmunity Branch at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health. Dr. Kaplan's research has focused on identifying mechanisms of organ damage and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity promotes end-organ damage in systemic lupus erythematosus, rheumatoid arthritis and other systemic autoimmune diseases. Recently, her research has focused on identifying abnormalities of neutrophil subsets and the role of neutrophil extracellular traps (NETs) in lupus, vasculitis and rheumatoid arthritis, both of which may contribute to the development of autoimmune responses and to end-organ damage. Dr. Kaplan also has an interest in identifying novel therapeutic targets that may prevent premature vascular damage in systemic autoimmunity, as well as the role of environmental triggers in the induction of autoimmunity. Moreover, she has led clinical trials to identify mechanisms that reduce blood vessel dysfunction in autoimmune and chronic inflammatory disorders.

Jill M. Norris

Colorado School of Public Health
Aurora, Colorado

Monica Purmalek

National Institute of Arthritis and Musculoskeletal and Skin Diseases/National Institutes of Health
Bethesda, Maryland

William H. Robinson

Stanford University; VA Palo Alto Health Care System
Stanford, California

Nickie Seto

National Institute of Arthritis and Musculoskeletal and Skin Diseases/National Institutes of Health
Bethesda, Maryland

Kristen Demoruelle


University of Colorado School of Medicine
Aurora, Colorado