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PD54-10: THE VALUE OF COMBINING LOW DOSE TROSPIUM CHLORIDE WITH TRANSCUTANEOUS POSTERIOR TIBIAL NERVE STIMULATION IN THE TREATMENT OF OVERACTIVE BLADDER IN FEMALES

Monday, May 15
11:00 AM - 11:10 AM
Location: BCEC: Room 159

Presentation Authors: Amr Abulseoud*, Gaber Ali, Mohamed Hassouna, Ahmed Moussa, Ibrahim Ibrahim, Emmanuel Saba, Alexandria, Egypt

Introduction: This study was done to verify whether the combination of transcutaneous posterior tibial nerve stimulation (TPTNS) with low dose trospium chloride in the treatment of females with overactive bladder (OAB) would be more effective than TPTNS alone after failure of behavioral therapy.

Methods: We randomized 30 women with OAB, in two groups: G I (15 patients) received 30 minutes TPTNS, three times a week; GII (15 patients) received TPTNS plus Low dose trospium chloride (20 mg once daily); all for 8 weeks. Patients were evaluated using Overactive Bladder Symptom Score questionnaire (OABSS) which includes 3 categories (score < 5 = mild symptoms, 6-11 = moderate symptoms, > 12 = severe symptoms), Incontinence Impact Questionnaire-short form 7 (IIQ-7) which includes 3 categories (score < 50% = good quality of life, 50-70% = moderate quality of life and > 70 = poor quality of life), 3 day voiding diary and urodynamics at weeks 0 and 8.

Results: The groups were similar before treatment. After treatment both groups improved regarding all the parameters, however group II showed more significant improvement. The OABSS was reduced from 13.0 ± 1.31 to 8.53 ± 1.30 (p<0.001) and from 12.67 ± 1.95 to 10.0 ± 2.0 (p<0.001) in GII and GI respectively. Improvement (change from one category to a better one) occurred in 8 (53.3%) and in 14 (93.3%) patients in GI and GII respectively. The mean IIQ-7 was reduced from 63.38 ± 8.81 to 31.99 ± 9.26 (p<0.001) for GII vs. 64.33 ± 8.57 to 51.86 ± 17.26 (0.002) for GI. Before treatment, 11 (73.3%) and 4 (26.7%) patients in each group had moderate and poor quality of life respectively. After treatment, 6 (40%) and 14 (93.3%) had good quality of life, 7 (46.7%) and 1 (6.7%) had moderate quality of life in GI and GII respectively. Two (13.3%) in GI had poor quality of life. The mean frequency for GII after treatment was 8.60 ± 0.83 instead of 12.87 ± 1.85 (p<0.001) before treatment, while it was reduced from 13.13 ± 1.64 to 10.60 ± 2.32 (p=0.003) in GI. The cystometric capacity improved from 263.40 ± 50.45 ml to 377.80 ± 112.92 ml (p=0.001) for GII Vs. 250.13 ± 56.24 ml to 296.40 ± 99.0 ml (p=0.026) for GI.

Conclusions: TPTNS combined with low dose trospium chloride proved to be more effective than TPTNS alone in the treatment of OAB in females.

Source Of Funding: none

Amr G. Abulseoud, MS

Alexandria University

Amr G. Abulseoud , Master of Urology (MS), Alexandria University.
I have been graduated from Alexandria University, Egypt since 2010 and finished my internship there in 2012 , I finished my Masters degree in 2016. I am now living and working in Alexandria.
I am highly interested in the field of Female Urology, Voiding dysfunction and Neurourology.

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PD54-10: THE VALUE OF COMBINING LOW DOSE TROSPIUM CHLORIDE WITH TRANSCUTANEOUS POSTERIOR TIBIAL NERVE STIMULATION IN THE TREATMENT OF OVERACTIVE BLADDER IN FEMALES



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