Poster, Podium & Video Sessions
Presentation Authors: Anup Shah, Daniel Shoskes*, Cleveland, OH
Introduction: Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is often associated with pelvic floor muscle spasm. While pelvic floor physical therapy (PT) is often effective, some men are unable to resolve their symptoms and have residual trigger points (TP). TP injection has been used for treatment in several neuromuscular pain syndromes. The objective of this study was to examine the efficacy and side effects of TP injection in men with CP/CPPS and pelvic floor spasm refractory to PT
Methods: Using an IRB approved Men's Health Registry we reviewed the records of all men with a diagnosis of CP/CPPS who received at least 1 TP injection. Patients were phenotyped with UPOINT (all had the T domain for tenderness of muscle) and symptoms measured with the NIH Chronic Prostatitis Symptom Index (CPSI). Response was measured by a 5 point Global Response Assessment (GRA) and change in CPSI (paired t test). For pelvic TPs, a pudendal block was done in lithotomy position and then each TP was identified transrectally by palpation. A nerve block needle was passed through the perineum into the TP confirmed by palpation. Between 0.5-1 cc was injected into each TP of a local anesthetic mixture (30:70 of 2% lidocaine and 0.25% bupivacaine). For anterior TPs, an ultrasound guided ilioinguinal block was done first and then each TP injected by direct palpation through the abdominal skin. Men were offered up to 3 sets of injections separated by 6 weeks each.
Results: We identified 37 patients who had a total of 68 procedures. 3 men had no followup after their first injection and were included for side effects but not for outcome. Indication was failure to progress on PT in 33, recurrent symptoms in 1 and refusal to do PT in 3. Mean age was 43.7 years (range 21-70) and median UPOINT domains was 3 (range 1-5). Initial total CPSI was 28.8+/-6.0. 16 men had 1 injection, 11 had 2 and 10 had 3. All had pelvic TPs injected and 9 also had anterior TPs. By GRA, 12 had significant improvement (35.3%), 10 had some improvement (29.4%), 11 had no change (32.3%) and 1 was worse (2.9%). Mean CPSI dropped from 28.7+/-6.1 to 21.8+/-7.2 (p<0.0001). 18 men had a drop of 6 or more points in CPSI (53%). Of note, none of 3 men who were noncompliant with PT had benefit. 3 men had temporary numbness in the lateral thigh after the injection (4.4%) and 1 had difficulty weight bearing on 1 leg for about 30 minutes.
Conclusions: TP injection in CP/CPPS patients as an adjunct to PT is well tolerated and leads to symptom improvement in about half, but is not a standalone cure. Durability and long term results are yet to be determined.
Source Of Funding: None
Daniel Shoskes is Professor of Urology at Cleveland Clinic. He is the director of the Novick Center for Clinical and Translational Research at the Glickman Urological and Kidney Institute. He completed his residency at the University of Toronto and Transplant Fellowships at the University of Oxford and at the Cleveland Clinic.
Saturday, May 13
7:00 AM – 9:00 AM
Saturday, May 13
4:00 PM – 6:00 PM