Poster, Podium & Video Sessions
Presentation Authors: Fabrizio Presicce*, Cosimo De Nunzio, Federica Puccini, Alberto Melchionna, Riccardo Lombardo, Andrea Tubaro, Rome, Italy
Introduction: To subtype patients with nocturia according to daily variations in the urine production and in the bladder capacity (BC).
Methods: Patients with ≥1 nocturia par day, both gender, were prospectively enrolled. Detailed medical history, body mass index (BMI), sonographic Post Void Residual (PVR) and a 3 days-FVC were collected. Patients with a PVR > 50 ml were excluded. Based on 3 days-FVC, frequency (24 hours, day-time, night-time), mean/minimum/maximum BC (24 hours, day-time, night-time), total voided volume (24 hours, day-time, night-time), Nocturia index (Ni) and Nocturnal Polyuria index (NPi) were assessed. Nocturnal Polyuria (NP) was defined as NPi > 20% in patients ≤ 35 years; > 33% in patients > 65 years; >20% + 2% every 5 years in patients between 35 and 65 years of age. BC was calculated by adding mean PVR to the micturition volume. Reduced BC was defined as a mean 24 hours BC < 200 ml. Severe nocturia was defined as ≥3 episodes per night. Patients were categorised in 4 subgroups according the presence/absence of NP and reduced BC.
Results: 84 patients were enrolled with a mean age of 62.6±13.5 years. 50/84 patients (59.5%) suffered from NP, and 50/84 patients (59.5%) had decreased BC. No gender difference in the incidence of NP and reduced BC were found. Patients with a reduced BC and NP presented a significant larger mean BC (p = 0.002) at night-time when compared to day-time and the highest number of nocturia episodes (3.2±1.6); patients with a normal BC and with NP presented a significant larger mean and maximum BC at night-time (p = 0.033 and p = 0.016, respectively) when compared to day-time (Table 1). In patients with reduced BC and without NP no significant variations in BC was observed between day-time and night-time (Table 1). On multivariate analysis BMI (OR: 1.28 per unit, 95%CI: 1.04-1.58; p = 0.019) and severe nocturia (6.26, 95%CI: 1.71-22.92, p = 0.006) were independent predictive factors for NP, while only severe nocturia (3.77, 95%CI: 1.20-11.83, p = 0.023) was an independent predictive factor for a reduced BC.
Conclusions: Patients with NP presented a different BC between day-time and night-time. Severe nocturia (≥3 episodes per night) predicts the presence of NP and a reduced BC. Our data suggest that in patients with severe nocturia both conditions should be considered and managed.
Source Of Funding: none