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MP94-02: Analysis of intravesical hyaluronic acid effectiveness on avoiding the development of actinic cystitis in patients during pelvic radiation therapy

Tuesday, May 16
7:00 AM - 9:00 AM
Location: BCEC: Room 253AB

Presentation Authors: Giuseppe Figiuolo*, William Leal, Etelvina Karditsa Moreno, Manaus, Brazil

Introduction: Actinic cystitis is a common manifestation resulting from radiotherapy treatment of pelvic malignancies. Exposure to radiation causes bladder histopathological changes, thus the urothelium of the bladder is replaced by an unusual layer of cells with eosinophilic infiltration. The main symptoms of actinic cystitis are urinary urgency, dysuria, urinary frequency and hematuria. The objectives of this study were to determine whether the hyaluronic acid intravesical instillation reduces the acute and late toxicity of radiotherapy and to assess the existence of side effects with the use of hyaluronic acid.

Methods: The research is a randomised clinical trial, was conducted at the Foundation Center of Amazonas State Oncology Control between August 2015 and July 2016. The patients participating in the study were divided into two groups: the control group and the group receiving the drug, random and randomly, all had begun to radiation treatment for cervical cancer. The monitoring included the evaluation of the toxicity of the bladder with 3, 6 and 9 months after the end of radiotherapy. The project was approved by the ethics committee of Foundation Center of Amazonas State Oncology Control in the opinion 1.456.189.

Results: We followed 35 patients, 18 in the control group and 17 in the intervention group. None of the patients who received instillations of hyaluronic acid had urinary symptoms of actinic cystitis, three patients (16.67%) of the control group showed acute cystitis (symptoms develop during or within three months after radiotherapy) and five (27.7%) had subacute cystitis (symptoms develop between 3-6 months after radiotherapy). No case of late actinic cystitis (symptoms develop 6 months after radiotherapy) was reported in either group, neither was reported any urinary infection or allergic reactions in the group where there was intervention.

Conclusions: The hyaluronic acid has shown effectiveness in the prophylaxis of actinic cystitis and its secure his administration.

Source Of Funding: Foundation Center of Amazonas State Oncology Control .

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MP94-02: Analysis of intravesical hyaluronic acid effectiveness on avoiding the development of actinic cystitis in patients during pelvic radiation therapy



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