Moderated Poster

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MP86-02: Prevalence of frailty among urological cancer patients in comparison with community-dwelling population

Monday, May 15
3:30 PM - 5:30 PM
Location: BCEC: Room 156

Presentation Authors: Shingo Hatakeyama*, Osamu Soma, Takuma Narita, Kazuhisa Tanaka, Toshikazu Tanaka, Daisuke Noro, Masaaki Oikawa, Yoshimi Tanaka, Teppei Matsumoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama, Hirosaki, Japan

Introduction: The prevalence of frailty is expected to increase due to the worldwide ageing. However, little is known about the prevalence of frailty in urological cancer patients. The aim of this study is to investigate the useful frailty assessment tools for urological cancer patients in comparison with community-dwelling population.

Methods: From August 2013 to March 2016, we evaluated 486 consecutive urological cancer patients in our hospital. Urological cancers included prostate cancer (PC, n=226), bladder cancer (BC, n=132), upper tract urothelial carcinoma (UTUC, n=42), and renal cell carcinoma (RCC, n=86). We retrospectively compared age and sex adjusted urological cancer patients and 2766 community-dwelling subjects who underwent frailty assessment including physical status (handgrip strength and gait speed), serum test (serum albumin and renal function), and mental status (exhaustion and depression). Gait speed was evaluated by timed get up and go test (TGUG). Independent factors that were significantly associated with tumor-bearing status were evaluated by multivariate regression analysis.

Results: The number of pair-matched patients in PC, BC, UTUC, and RCC were 212, 130, 41, and 84. TGUG, handgrip strength, and serum albumin were significantly worse in all types of cancers than controls. Renal function was significantly better in PC, whereas it was worse in BC, UTUC, and RCC than controls. The number of patients with exhaustion or depression were significantly higher in PC. Multivariate regression analysis showed TGUG and serum albumin were significantly associated with tumor-bearing status.

Conclusions: Urological cancer patients were significantly frail compared with community-dwelling older adults. Our results provide a picture of the prevalence of frailty in urological patients. TGUG and serum albumin may be simple and useful tools for frailty assessment in urological cancer patients.

Source Of Funding: none

Shingo Hatakeyama

Hirosaki University Graduate School of Medicine

SHINGO HATAKEYAMA, M.D.
Assistant Professor, Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki , JAPAN
Research interests: general urology, urological surgery, urothelial cancer, urological oncology, renal transplantation, urinary stone disease, end-stage renal disease, basic research, glycobiology

Grants
Research Project Number: 23791737, 23791740, 24659708, 17K11119. Japan Society for the Promotion of Science
The 4th Young Research Grant, 2011. Japanese Urological Association

Honors
AKITA Medical Award (2004)
Hirosaki University Hospital incentive award for Clinical skills (2006)
JUA Best Poster Award (2005, 2009, 2011, 2011)
EAU best poster Awards (2014, 2017)
JUA Award (2015)

Peer-Reviewed Journal Articles
1. Hatakeyama S., Ohyama C., Minagawa S., et al. Cancer Res. 2004 June. 64: 4257-4262.
2. Hatakeyama S, Sugihara K, Lee SH, et al. Enhancement of human sperm motility by trophinin binding peptide J Urol. 2008 Aug;180(2):767-71.
3. Hatakeyama S, Sugihara K, Nakayama J , et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3095-100.
4. Lee SH, Hatakeyama S, Yu SY, et al. . J Biol Chem. 2009 Apr 24.
5. Bao X, Kobayashi M, Hatakeyama Set al. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12109-14.
6. Bao X, Moseman EA, Saito H, Hatakeyama S, et al. Immunity. 2010 Nov 24;33(5):817-29.
7. Tsuboi S, Sutoh M, Hatakeyama S, et al. . EMBO J 2011 Jun 28;30(15):3173-85.
8. Hatakeyama S, Sugihara K, Shibata TK, et al. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19587-92.





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MP86-02: Prevalence of frailty among urological cancer patients in comparison with community-dwelling population



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