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MP40-08: CCL7, a stem cell homing factor, has low responsive expression during sling procedure associated with postpartum urinary incontinence

Saturday, May 13
3:30 PM - 5:30 PM
Location: BCEC: Room 153

Presentation Authors: Qi-Xiang Song, Shanghai, China, People's Republic of, Hai-Yan Li, Ling Qing, Xiang-xiang Ye, Wenzhou, China, People's Republic of, Limin Liao, Beijing, China, People's Republic of, Hai-Hong Jiang*, Wenzhou, China, People's Republic of

Introduction: Chemokine (C-C motif) ligand 7(CCL7) is one of key factors homing stem cell to rescue injured urethra and related pudendal nerve for maintaining urinary continence, which increases in significance immediately after simulated birth injury. To explore if serious stress urinary incontinence (SUI) after birth injury has low CCL7 responsive expression at the local injury of urethra.

Methods: 437 SUI patients preparing for sling procedure enrolled in the study for testing CCL7 expression via collection the blood sample from systematic vein (baseline expression) and local incision (responsive expression), and for inquiry a history if having SUI at last vaginal delivery. 411 individuals successively completed a simplified urinary incontinence inquiry to their last vaginal deliveries. 380 individual blood samples were effectively collected and tested. 352 SUI patients with both above data were analyzed and then assigned to 4 groups according to postpartum no SUI, mild SUI (<1/ week), severe SUI (every day), and moderate SUI (between mild and severe).

Results: There were no significant differences at baseline expression of CCL7 between 4 groups. Compared to postpartum no SUI, the responsive expression of CCL7 was significantly low in the group of postpartum severe SUI (p<0.05). When CCL7 responsive expression standardized to the baseline expression, both groups of severe SUI (p<0.05) and moderate SUI (p<0.05) have lower CCL7 expression than group of postpartum no SUI.

Conclusions: The study demonstrated low local CCL7 responsive expression during sling procedure associated with postpartum SUI. CCL7 could become a biomarker indicating the risk of postpartum SUI. Delivery CCL7 might be an effective way to improve urinary continence immediately after birth injury.

Source Of Funding: NSF China 81670695; China America Promotion Society for Medical Doctors (CAPs MD)

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MP40-08: CCL7, a stem cell homing factor, has low responsive expression during sling procedure associated with postpartum urinary incontinence



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