Moderated Poster

Poster, Podium & Video Sessions

MP29-20: Treatment Effectiveness in Interstitial Cystitis/Bladder Pain Syndrome: Do patient perceptions align with efficacy based guidelines?

Saturday, May 13
9:30 AM - 11:30 AM
Location: BCEC: Room 151

Presentation Authors: Avril Lusty*, Kingston, Canada, Elizabeth Kavaler, Kay Zakariasen, New York, NY, Victoria Tolls, J. Curtis Nickel, Kingston, Canada

Introduction: Evidence from clinical treatment trials in interstitial cystitis/bladder pain syndrome (IC/BPS) are employed to develop treatment guidelines. Do patients&[prime] perceptions of success or failure of those specific therapies align with that of available clinical trial data?

Methods: 1628 adult females with a self-reported diagnosis of IC completed a web based survey in which patients described their perceived outcomes with the therapies they were exposed to. Previously published literature used in part to develop IC/BPS guidelines provided the clinical trial data outcomes. Patient reported outcomes were compared to available clinical trial outcomes and published treatment guidelines.

Results: Based on patient perceived outcomes (benefit:risk ratio), the most effective treatments were opioids, phenazopyridine, and alkalizing agents with amitriptyline and antihistamines reported as moderately effective. The only surgical procedure with any effectiveness was electrocautery of Hunner&[prime]s lesions. In order of efficacy reported in the literature, the therapies for IC/BPS with predicted superior outcomes should be: cyclosporine A, amitriptyline, hyperbaric oxygen, pentosan polysulfate plus subcutaneous heparin, botulinum toxin A plus hydrodistension, and L-arginine. While some of the guideline recommendations aligned with patient reported effectiveness data, there was a general disconnect between guidelines and effectiveness reported in clinical practice.

Conclusions: There is a disconnect between real world patient perceived effectiveness of IC/BPS treatments compared to the efficacy reported from clinical trial data and subsequent guidelines developed from this efficacy data. Optimal therapy must include the best evidence from clinical research but should also include real life clinical practice implementation and effectiveness.

Source Of Funding: Canadian Institute of Health Research

Avril Lusty, MD

Queen's University

Dr. Avril J. Lusty, MD, Department of Urology, Queen's University

Bachelor of Science from University of Guelph
Doctor of Medicine from Queen's University
Resident from Queen's University, Department of Urology, Kingston, Ontario, Canada
Interests: oncology, transplant, resident education, competency based medical education, functional urology
First attendance of the AUA meeting, presenting a moderated poster




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