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MP18-07: The accuracy and validation of multiparametric magnetic resonance imaging (mpMRI) using PI-RADS v2 in disease upgrading on re-biopsy among patients with low-risk prostate cancer on active surveillance (AS) – A Brazilian perspective.

Friday, May 12
3:30 PM - 5:30 PM
Location: BCEC: Room 153

Presentation Authors: Públio Viana*, Natally Horvat, Rodrigo Pessoa, Thiana Rodrigues, Giuliano Guglielmetti, Rafael Coelho, Rubens Park, São Paulo, Brazil, Herbert Alberto Vargas, New York, NY, Willian Nahas, São Paulo, Brazil

Introduction: The current selection criteria to AS is critical, it becomes even more relevant in Latin America, given the higher proportion of high risk cancers.
The objective of this study is to analyze the accuracy of mpMRI using PI-RADS v2 in predicting the risk of upgrading on re-biopsy (UR) in men with low-risk PCa on AS.

Methods: In this Institutional Review Board approved prospective study, patients with low-grade PCa selected for AS at our institution underwent mpMRI at least 6 weeks after the baseline 12-core random prostate biopsy (BSB), from March 2014 to March 2016. One blinded abdominal radiologist evaluated the exams regarding presence of dominant lesion and assigned the PI-RADS v2 score. MRI-target TRUS guided re-biopsies were done in all patients within 6-12 months after the BSB. Standardized 12-core biopsy was performed and additional cores were taken from suspicious areas on mpMRI.

Results: One hundred and nine patients were included, 93 (85.3%) patients had a dominant lesion on MRI. mpMRI were classified as PI-RADS 1, 2 or 3 in 67 (61.5%) patients, and as PI-RADS 4 or 5 in 42 (38.5%) patients. UR occurred in 42 (38.5%) patients. Out of these, 39 (92.8%) had radical prostatectomy, 6 (15.4%) T2a, 24 (61.5%) T2b, and 9 (23.1%) T3a. The proportion of UR among PI-RADS categories is shown in table 1. The diagnostic performance of mpMRI for PCa upgrading after re-biopsy was summarized in table 2. Patients assigned as PI-RADS 4 or 5 presented a significantly higher risk for UR compared with patients with PI-RADS 1, 2 or 3 (73.8% vs 16.4%, p<0.001). Logistic regression analyses demonstrated that PI-RADS 4 or 5 remained a significant predictor of UR (OR: 37.366, p<0.0001).

Conclusions: We demonstrated in our population that mpMRI using PI-RADS v2 is a significant predictor for upgrading on re-biopsy in patients on AS and could be used to guide TRUS biopsy, increasing the accuracy of current clinical criteria for AS.


Source Of Funding: The authors have no funding, or financial relationships.

Públio Cavalcante Viana, MD

Institute of Radiology (InRad), Clinics Hospital, University of São Paulo (FMUSP) – São Paulo/Brazil,

Publio Viana MD
Radiologist at Sirio Libanes Hospital- Sao Paulo -Brazil
Radiologist at Radiology Institute of Sao Paulo University- Sao Paulo -Brazil
I serve as the Director of Genitourinary Radiology at Radiology Institute and Cancer Institute of Sao Paulo University, and have a particular interest in studying cancers involving the urinary system (e.g. prostate, bladder, and kidneys) and the female reproductive organs (e.g. uterus and ovaries).

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MP18-07: The accuracy and validation of multiparametric magnetic resonance imaging (mpMRI) using PI-RADS v2 in disease upgrading on re-biopsy among patients with low-risk prostate cancer on active surveillance (AS) – A Brazilian perspective.



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