Moderated Poster

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MP16-16: Is there any difference in prognosis between synchronous and metachronous brain metastasis from metastatic renal cell carcinoma?

Friday, May 12
1:00 PM - 3:00 PM
Location: BCEC: Room 253AB

Presentation Authors: Se Young Choi, Jeman Ryu, Jae Hyeon Han*, Wonchul Lee, Han Kyu Chae, Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim, Seoul, Korea, Republic of

Introduction: The prognosis of renal cell carcinoma (RCC) brain metastasis (BM) is relatively poor. We evaluated the oncological outcomes of synchronous and metachronous BM of metastatic RCC according to local or systemic therapy.

Methods: Metastatic RCC patients (n=93) with synchronous and metachronous BM were retrospectively identified. We analyzed patients and tumor characteristics, treatment method, prognostic factors, BM progression and overall survival (OS). Synchronous BM was compared with metachronous BM using multivariable Cox regression.

Results: 76 patients (81.7%) received local therapy (stereotactic radiosurgery [60.0%], radiation therapy [23.5%], neurosurgery [10.1%]) and 54 patients (58.1%) were treated with systemic medical therapy. Median OS after diagnosis of BM were 9.2 months. In multivariable analysis, sarcomatoid component (hazard ratio [HR] 2.807, 95% confidence interval [CI] 1.088-7.239, p=0.0328) and multiple BM (HR 3.177 95% CI 1.561-6.469, p=0.0014) were significant factors for BM progression. MSKCC poor risk (HR 3.672, 95% CI 1.441-9.36, p=0.0064), sarcomatoid component (HR 4.264, 95% CI 2.062-8.820, p=0.0001) and multiple BM (HR 2.838, 95% CI 1.690-4.767, p=0.0001) were prognostic factors for worse OS. In addition, local treatment (HR 0.436, 95% CI 0.237-0.802, p=0.0076) and systemic treatment (HR 0.322, 95% CI 0.190-0.548, p<0.0001) were also independent factors for better OS. Although the OS from initial RCC diagnosis in metachronous BM patients was longer than synchronous BM patients, there was no difference between synchronous and metachronous in BM progression and OS after diagnosis of brain metastasis.

Conclusions: MSKCC poor risk, sarcomatoid component of histology, and multiple BM were poor prognostic factors for OS. Systemic or local treatment improved OS, but the type of synchronous and metachronous BM did not influence BM progression and OS.

Source Of Funding: none

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MP16-16: Is there any difference in prognosis between synchronous and metachronous brain metastasis from metastatic renal cell carcinoma?



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