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MP08-06: Combination of RGB and narrow band imaging for discrimination of non-muscle invasive bladder cancer

Friday, May 12
9:30 AM - 11:30 AM
Location: BCEC: Room 160

Presentation Authors: Kwang Suk Lee*, Kyo Chul Koo, Do Kyung Kim, Jongsoo Lee, Jong Won Kim, Jae Yong Jeong, Sung Ku Kang, Byung Ha Chung, Seoul, Korea, Republic of

Introduction: We evaluated the use of white light imaging (WLI) and narrow-band imaging (NBI) cystoscopy for the detection of bladder cancer. Additional objectives were to provide summary RGB data and to determine a relationship between cancer detection and tumor characteristics.

Methods: A prospective double blinded controlled study of NBI was conducted in 102 consecutive patients with definite or suspected bladder cancer after WLI and NBI cystoscopy by 2 urologists. Transurethral targeted biopsies were performed and the histologic outcomes were compared. We analyzed average RGB color on 3x3 pixel of the randomized 3 other points for abnormal lesions and grossly normal in bladder.



Results: A total of 172 biopsies for suspicious lesions (WLI+/NBI+=145, WLI-/NBI+=27) were taken. The percentage of malignancies in the sites identified only by NBI was 63.0% (17 sites).Of 15 CIS sites, 53.3% was detected by only NBI. The positive predictive value of NBI and WLI were 70.3% and 67.1%, respectively.
Bladder washing cytology positive (HR=3.87, p=0.002). grossly papillary feature (HR=6.80, p<0.001) average blue of lesion for WLI (HR=0.96, p=0.006) were significant risk factors for detection of bladder cancer during transurethral targeted biopsy.

Conclusions: NBI is a simple and effective method for identifying CIS without the need for dyes. RGB analysis for bladder wall would be helpful for discrimination bladder cancer.

Source Of Funding: none

Kwang Suk Lee

Yonsei University College of Medicine

Professor Kwang Suk Lee, MD
Department of Urology, Yonsei University College of Medicine
Gangnam Severance Hospital, Seoul, Korea


Dr. Kwang Suk Lee, MD, works in department of Urology at Yonsei University College of Medicine, Seoul, Korea. He graduated from Yonsei University College of Medicine in 2010, completed his residency at Severance Hospital. Research focuses on the field of prostate cancer and benign prostate hyperplasia.

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