Plenary: Next Frontier, Sunday

Plenary: Next Frontier

PNFLBA-05: Late-Breaking Abstract - Polyurethanes for Urinary Stents: A Study on Materials' Stone Encrustation Performances

Sunday, May 14
1:20 PM - 1:25 PM
Location: BCEC: Ballroom East

Presentation Authors: Gary Li*, Jun Li, Zheng Zhang, Morgan Tierney, Cambridge, MA

Introduction: Many studies have looked at infection and encrustation resistance capabilities of commercial 'polyurethane' (PU) compared to silicone [Tunney et al., 1996; Gorman et al., 1998; Bithles, 2004], but few have specified the exact PU composition [Park et al., 2002] and none have considered multiple subtypes.

The objective of this study was to determine the amount of encrustation formed on multiple PU subtypes compared to silicone.


Methods: A continuous flow in vitro model of the bladder was built and validated, and the widely accepted artificial urine formulation by Tunney et al was chosen [5]. Experiments were done in duplicate, testing commercial polycarbonate PU, polyether PU, and polyester PU against silicone, the gold standard (n = 4). Over five days with daily solution refresh, measurements for calcium encrustation content were taken via o-Cresolphthalein (oCPC) method. One-way ANOVA and Fisher's Pairwise Comparison were used for statistical analysis.

Results: Results showed significant reductions of encrustation on polyether PU and polyester PU compared to silicone (p-values < .0001) and similar levels of encrustation on polycarbonate PU compared to silicone (p-values < .510).

Conclusions: This study showed how polycarbonate PU encrusted much more than polyether and polyester PU, though all three are called 'polyurethane.' Furthermore, results suggest polyester and polyether PU perform better than silicone in terms of encrustation resistance. Future work includes clinical trials to confirm results.

Note: The first experiment was done before the submission deadline and the duplicate experiment was done after the submission deadline to confirm findings.

Source Of Funding: Teleflex Inc.

Gary Li, MS

Tufts University

Gary Li is a researcher from Tufts University graduating with a M.S. degree this May. His graduate research was conducted through Teleflex Inc, and his findings will be transfered to a manufacturing facility in Ireland. His work was advised by Zheng Zhang, Ph.D., and David Kaplan, Ph.D.

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PNFLBA-05: Late-Breaking Abstract - Polyurethanes for Urinary Stents: A Study on Materials' Stone Encrustation Performances



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