Category: Schizophrenia / Psychotic Disorders

Symposium

Predictive Biomarkers of Neural System Engagement With Initial Exposure to Procognitive Interventions for Schizophrenia

Saturday, November 18
12:00 PM - 1:30 PM
Location: Aqua Salon E & F, Level 3, Aqua Level

Keywords: Neuroscience | Schizophrenia | Information Processing
Presentation Type: Symposium

Advances in neuroscience have transformed our understanding of both impaired and healthy brain functions in psychotic illnesses. Despite substantial progress, few if any laboratory tests have made their way into clinics where they might inform diagnoses or predict response to treatments. Development of effective treatments for cognitive impairments associated with psychosis has been hindered by a lack of direct measures of brain function that are sensitive to the neural systems engaged by pro-cognitive interventions. This presentation will show that EEG measures of early auditory information processing (EAIP) offer promise for improving our understanding and treatment of psychotic illnesses. EAIP measures account for substantial portions of variance in clinical, cognitive, and psychosocial functioning in schizophrenia. Recent structural equation modeling results from N=1415 schizophrenia patients reveal pathways through which EAIP affects cognition, symptoms, and, ultimately, psychosocial functioning will be presented. Results from proof of concept pharmacologic and cognitive training studies confirm that measures of EAIP are sensitive to, and predict, response to some pro-cognitive interventions. These findings suggest that EEG measures of EAIP can contribute to future large-scale biomarker-guided treatment strategies that target the cognitive impairments associated with psychosis. 

Gregory Light

Professor and Deputy Vice Chair, Psychiatry
University of California, San Diego

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