Category: Bipolar Disorders

Symposium

Inflammation in Overweight and Obese Patients With Bipolar Disorder

Friday, November 17
8:30 AM - 10:00 AM
Location: Aqua 300 A & B, Level 3, Aqua Level

Keywords: Bipolar Disorder | Obesity / Overweight
Presentation Type: Symposium

Introduction: Individuals with bipolar disorder experience inflammatory and other cardiovascular risk, such as obesity and sedentary lifestyle. This pilot study examines the efficacy of a lifestyle intervention, or Nutrition, Exercise, and Wellness Treatment (NEW Tx), to reduce inflammation and improve overall cardiovascular risk for overweight individuals with bipolar disorder.


Methods: Participants (N=39) were randomized to either NEW Tx (a weekly, individualized lifestyle intervention for 16 weeks and then bi-weekly for the remaining 4 weeks) or a wait list control. All assessments were conducted a pre-treatment (week 0) and post-treatment (week 20). We collected inflammatory markers (C - reactive protein (pg/ml), IL-1β (pg/ml), IL-6 (pg/ml), IL-8 (pg/ml) and TNFa (pg/ml) before (Week 0) and after (Week 20) the 20-week lifestyle intervention. 


Results: Participants with inflammatory marker data (N=32) had the following C - reactive protein levels at baseline, M = 3,852,104 pg/ml (SD = 7,767,7300). With respect to IL-1β, IL-6, IL-8 and TNFα, we observed the following levels at baseline M =1.67 pg/ml (SD =1.48), M = 2.93 pg/ml (SD = 3.30), M = 11.09 pg/ml (SD = 8.10) and M = 4.38 pg/ml (SD = 3.69), respectively. For participants who had pre- and post-treatment data on inflammatory markers (N=6), we did not observe significant changes over the study duration (p’s > .05; Cohen’s D; .267 for C-reactive protein; .214 for IL-1β; ,545 for IL-6; .520 for IL-8; .899 for TNFα).


Discussion: These findings provide further support to the immune dysregulation model used to explain the clinical features of bipolar disorder. These data also suggest that additional research is warranted to better understand inflammation in bipolar disorder. 

Louisa G. Sylvia

Assistant Professor
Massachusetts General Hospital/Harvard Medical School

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