Category: Bipolar Disorders
Keywords: Bipolar Disorder | Neuroscience
Presentation Type: Symposium
Background: Bipolar disorder (BD) is among the most heritable forms of mental illness, and aberrant inflammatory pathways are salient to BD, however little is known about the relevance of inflammatory genetic markers to BD. This study focuses on the association of the interleukin 1β single nucleotide polymorphism rs16944 with brain structure and cognitive flexibility among adolescents with BD and healthy control (HC) adolescents.
Methods: Structural magnetic resonance imaging scans were performed on 41 BD and 56 HC adolescents (13-19 years) matched for age and sex. Analyses focused on regions of interest: hippocampus, amygdala, dorsolateral prefrontal cortex, and caudal anterior cingulate cortex (ACC). Cognitive flexibility was assessed via the intra/extradimensional shift (IED) task (Cambridge Neuropsychological Tests Automated Battery subtest) for 42 BD and 54 HC adolescents. Saliva was collected using DNA Genotek Oragene-500 kits. Genotyping was done using standard LifeTechnologies TaqMan® procedures on the Applied Biosystems 7500 Sequence Detection for the following.
Results: There was a main effect of rs16944 on caudal ACC surface area; T allele carriers had reduced surface area when compared to non-carriers (1500.8mm2 versus 1602.5mm2; F=6.409, p=0.013). No group x gene interactions were observed. There was no main effect of rs16944 on cognitive flexibility in the overall sample. Within BD adolescents, A allele carriers completed more stages of the IED task than non-carriers (U= 291.50, p=0.004). No significant genetic-related differences were seen within HCs.
Conclusions: These findings suggest that the impact of IL-1β rs16944 on brain structure is similar in BD and HC adolescents, its impact on cognitive flexibility differs by group, and different alleles impact brain structure and neurocognition. Studies examining circulating levels of IL-1β protein are warranted to parse state from trait genetic effects.
Sunnybrook Health Sciences Centre
Friday, November 17
8:30 AM – 10:00 AM
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