Category: Suicide and Self-Injury

Symposium

Symposium 47 - Bench to Bedside: Understanding Suicide Prevention From Biomarkers to Implementation Science

Friday, November 17
1:45 PM - 3:15 PM
Location: Cobalt 502, Level 5, Cobalt Level

Keywords: Suicide | Prevention | Evidence-Based Practice
Presentation Type: Symposium

Suicide is a major public health concern. The age-adjusted suicide rate is 13.26 per 100,000 people annually in the United States and overall rates of suicide have increased steadily since 1999 (CDC, 2015). Suicide is a leading and increasing cause of death among young adults and adolescents (Heron, 2016). Rates are also increasing in middle-aged adults (Hempstead & Phillips, 2015).  Given these alarming statistics, urgent attention to this public health crisis is warranted.


A bench to bedside approach has been recommended to advance progress toward identifying new interventions by reducing traditional silos between basic and clinical research (NIH, 2016). We have the rare opportunity to advance suicide research by presenting data on a series of projects which include biomarkers, effectiveness trials, and implementation science.


 


First, Dr. Alexander B. Niculescu will represent the basic science end of the bench to bedside continuum. He will present results of studies to develop blood biomarker tests for suicide risk prediction, and the use of those biomarkers to stratify individuals for precision medicine approaches. Additionally, an app for suicide risk prediction, Convergent Functional Information for Suicidality (CFI-S), was developed, and results from its use in various settings, alone or in synergistic combination with biomarker tests, will be discussed.


Then, moving from bench to clinical, Dr. Kate Comtois will present effectiveness and feasibility data from two pragmatic trials of suicide-focused interventions conducted within the Department of Defense – the Collaborative Assessment and Management of Suicidality (CAMS) and caring contacts via text message studies. Results will be discussed in the context of civilian completed and on-going pragmatic clinical trials which will inform efforts to resolve suicidality in real-world settings.


Next, Dr. Shari Jager-Hyman will discuss the results of a trial of Cognitive Therapy for Suicide Prevention (CT-SP) in outpatient community mental health. Results of this study indicated that CT-SP, delivered in the community by non-expert therapists, was effective in lowering repeat suicide attempt rates among adults.


Finally, Dr. Rinad Beidas will complete our journey along the bench to bedside continuum by representing the field of implementation science. Specifically, Dr. Beidas will discuss her ongoing study which partners with stakeholders to understand how to implement the three firearm components of Safety Check, an evidence-based approach for promoting safe firearm storage, as a suicide prevention strategy in pediatric primary care.


Our discussant, Dr. Joan Asarnow, will discuss implications of the four presentations on the advancement of research on suicide. She will also highlight future directions in light of these findings for moving the needle forward on this seemingly intractable public health crisis.

Learning Objectives:

Rinad Beidas

Assistant Professor
University of Pennsylvania

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Courtney Benjamin Wolk

University of Pennsylvania

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Joan Asarnow

UCLA

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    Alexander Niculescu

    Indiana University

    Presentation(s):

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    Katherine Comtois

    University of Washington

    Presentation(s):

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    Shari Jager-Hyman

    University of Pennsylvania

    Presentation(s):

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    Rinad Beidas

    Assistant Professor
    University of Pennsylvania

    Presentation(s):

    Send Email for Rinad Beidas


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