Category: Bipolar Disorders

Symposium

Symposium 3 - Understanding the Underlying Mechanisms of Bipolar Disorder: Preliminary Data on Inflammation

Friday, November 17
8:30 AM - 10:00 AM
Location: Aqua 300 A & B, Level 3, Aqua Level

Keywords: Bipolar Disorder | Adolescents | Obesity / Overweight
Presentation Type: Symposium

Preclinical and clinical translational research indicate that disturbances in inflammation may play a role in the pathophysiology of psychiatric disorders. The increased incidence of inflammatory diseases in individuals with bipolar disorder (e.g., cardiovascular disease, obesity, autoimmune diseases) provides evidence that inflammatory mediators may be involved in the underlying mechanisms of bipolar disorder. Dr. Nusslock will set the stage for this symposium by introducing his “neuroimmune network hypothesis” which offers an in depth, evidence-based theory on how inflammation may mediate early-life adversity and later cardiovascular and psychiatric risk. Dr. Goldstein will discuss findings from his recent study on the association of an inflammatory genetic marker, or interleukin 1β single nucleotide polymorphism rs16944, with brain structure and cognitive flexibility among adolescents with bipolar disorder compared to healthy controls. Dr. Miklowitz will present recent data on inflammatory markers in adolescents with bipolar disorder. Dr. Sylvia will present levels of inflammatory markers in obese patients with bipolar disorder. Together, these talks will bring evidence on cell metabolism and inflammation to the clinical setting to further our understanding of the mechanics of mood episodes.  In the discussion, the speakers will address the therapeutic implications of these findings. 

Learning Objectives:

Louisa G. Sylvia

Assistant Professor
Massachusetts General Hospital/Harvard Medical School

Presentation(s):

Send Email for Louisa Sylvia

Eric A. Youngstrom

Professor and ABCT Fellow
University of North Carolina

Presentation(s):

Send Email for Eric Youngstrom

Robin Nusslock

Associate Professor, Department of Psychology
Northwestern University

Presentation(s):

Send Email for Robin Nusslock

Benjamin Goldstein

Associate Professor
Sunnybrook Health Sciences Centre

Presentation(s):

Send Email for Benjamin Goldstein

David Miklowitz

Professor
UCLA Semel Institute

Presentation(s):

Send Email for David Miklowitz

Louisa G. Sylvia

Assistant Professor
Massachusetts General Hospital/Harvard Medical School

Presentation(s):

Send Email for Louisa Sylvia


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