Category: Transdiagnostic

Symposium

Diathesis-Stress Models Involving Neuroticism and Its Facets in the Prediction of Episodes of Major Depressive Disorder in Late Adolescence

Sunday, November 19
10:15 AM - 11:45 AM
Location: Indigo Ballroom A, Level 2, Indigo Level

Keywords: Depression | Stress | Longitudinal
Presentation Type: Symposium

Neuroticism, dysfunctional attitudes, negative inferential style, sociotropy, autonomy and anxiety sensitivity have been proposed to be vulnerability factors for unipolar mood disorders (UMDs) and/or anxiety disorders (ADs).  We have previously found that of these vulnerabilities, Neuroticism is a unique prospective predictor of major depressive episodes (MDEs). However, prospective tests of diathesis-stress models involving these vulnerabilities and major stressful life events (SLEs) have been rate to date.  The purpose of this study was to prospectively test diathesis-stress models involving these vulnerabilities with initial onsets and recurrences of MDEs.


The study analyzed five years of follow-up diagnostic data from the Structured Clinical Interview for DSM-IV among 547 high school juniors recruited as part of the Youth Emotion Project in suburban Chicago and Los Angeles areas who completed at least one of the five annual follow-up interviews.  At baseline, all participants completed a lifetime SCID and a battery of self-report vulnerability questionnaires.  At baseline and each follow-up interview, all participants completed the UCLA Life Stress Interview (LSI).  Results from latent variable, survival analyses indicate that the main effects of Neuroticism and several forms of life stress but not their interaction were significant in predicting both initial onsets and recurrences of MDEs (above and beyond the effects of a history of having a prior MDE). These results provide support for additive but not multiplicative diathesis-stress models involving Neuroticism for the prediction of MDEs. 

Amanda Kramer

Graduate Student
Northwestern University

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Diathesis-Stress Models Involving Neuroticism and Its Facets in the Prediction of Episodes of Major Depressive Disorder in Late Adolescence



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